Hypoxia governs signalling pathways involved in the regulation of muscle mass. While many studies show its macroscopic effects, its role at the molecular and cellular levels remains incompletely elucidated. Our work is therefore focused on the regulation, at the cellular level, of muscle mass and protein balance in skeletal muscle implicated in high-intensity intermittent exercise and resistance training in hypoxia .
The aim of this project is to identify the signalling pathways involved in the control of muscle mass and metabolism during exercise in hypoxia, and more specifically the role of the Hippo and IL-6/STAT3 signalling pathways.The goal of this research is to study the optimal altitude to potentiate the effects of hypoxia on health. To understand how hypoxia induces these positive adaptations, different cellular mechanisms are studied. In particular, the regulation of the content and dynamics of mitochondria during exercise, but also the inter-organ communication mediated by small extracellular vesicles called exosomes.
